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OECD Global Chemicals Knowledge Base

15 October 2017

The Organisation for Economic Co-operation and Development (OECD) is considering maintaining or supporting a Global Chemicals Knowledge Base (GCKB) and seeks industry feedback on how best this might operate.

The GCKB is a reaction to the continuing growth of knowledge on the properties of chemicals and the related proliferation of databases capturing some aspects of this information. There has been an expressed need in a number of OECD Expert Group meetings and in other international fora, for a consolidated Global Chemicals Knowledge Base (GCKB) that can be used to support chemical safety activties. This builds on an OECD vision to move towards seamless integration of a range of tools and databases based on standardised templates for reporting chemical test summaries (i.e. the  OECD Harmonised Templates (OHTs) to ensure interoperability between all the OECD products.

One type of GCKB that could be envisioned is, for example, a knowledge base that contains hazard (both apical endpoint and intermediate effects) and physical-chemical properties on chemicals, and use information, captured in an OHT-based format.  This GCKB could then service other applications such as grouping and read-across (QSAR Toolbox), AOP development and subsume or extend the eChemPortal.  Alternatively, the GCKB could start with an existing system like the AOP-KB to gradually make links between mechanistic and apical knowledge.

The amassed information in a GCKB could be used by countries to aid in prioritisation, assessment and management of chemicals or for other applications such as the development of Thresholds of Toxicological Concern.  Depending on the scope it could also inform predictive toxicology, better environmental monitoring, development of artificial intelligence, machine learning or data mining applications.

A new survey has been created by OECD thtat aims to capture the needs and expectations of users of such a knowledge base and solicit input from members and stakeholders involved in the OECD Chemicals Program.  

The survey is to be completed by entering responses via the following link: http://survey.oecd.org/Survey.aspx?s=6f67f41794bf417b99b3b97f046609f5

The mission of the OECD is to promote policies that will improve the economic and social well-being of people around the world. Further information is available at http://www.oecd.org/

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